2020-12-10 08:02:47

Prelude

Today’s topics

  • Review for Exam 4
    • Thursday, December 17, 6:50 PM - 8:40 PM, open noon - 9:00 PM
  • Frontiers in neuroscience
  • Careers in neuroscience
  • The Cerebral Symphony

History

  • Descartes thought ____ about the ____
  • Fluid from the cerebral ventricles was once thought to ____

Methods

  • Single unit recordings have ____ spatial and ____ temporal resolution.
  • EEG has____ spatial and ____ temporal resolution.
  • Single unit recordings measure ____; EEG measures ____.

Anatomy

  • Directional terms, slices
    • In the human forebrain ____ and superior overlap.
  • Gross
    • The ____ means “little brain” in Latin; it’s located adjacent to _____.
    • The ____ and ____ in the midbrain release dopamine
    • The ____ controls endocrine and ANS activity.

  • Gross anatomy
    • The insula is located deep inside the ____.
    • Forebrain/midbrain/hindbrain
    • ventricles/CSF, meninges, blood supply
    • Gyri/sulci
    • lobes, insula/insular cortex
    • gray/white matter

Cellular anatomy

  • Neurons receive most of their input on the ____ and ____.
  • Gray matter is made of ____; white matter is made of ____.

Neurophysiology

  • Resting potential
    • In neuron at rest, ____ inside is greater than outside; What force(s) ____ push [Na+] inward?
  • Ca++ influx is involved in ____, ____, and ____.
  • EPSP/IPSPs are ____ than action potentials

  • Nodes of Ranvier contain lots of ____-gated channels
  • The absolute refractory period occurs when voltage-gated Na+ channels ____
  • Action potential phases, causes/components
  • Synaptic transmission
    • EPSPs, IPSPs
  • Synaptic plasticity, LTP, NMDA receptors

Neurochemistry

  • ‘Big Three’ – Glu, GABA, ACh
  • Neuromodulators – DA, NE, 5-HT
  • Hormones
    • Oxytocin, vasopressin are released from ____.
  • Can we readily measure neurotransmitter levels in the brain?

Evolution and development

  • There is a “mammalian” brain plan (True/False)

Emotion

  • The ____ lobe contains the amygdala
  • Pleasure/reward systems, key brain areas and neurotransmitter(s)
  • Fear, stress in behavior and brain
    • Acute vs. chronic stress

Perception and Action

  • Sensory fibers enter the (dorsal/ventral) spinal cord. Motor fibers exit from the (dorsal/ventral) spinal cord.
  • Parietal lobe contains ____ cortex
  • Photoreceptor cells release more neurotransmitter in (darkness/light)
  • Can’t see reddish-green because long (“red”) and medium (“green”) cones ____

  • Areas of cortex devoted to moving fingers, tongue are (large/small)
  • Most retinal ganglion cells project to the ____
  • Sound direction is signaled by ____
  • Minty flavors taste `cool’ because…
  • Topographic maps: somatosensation, audition, vision

  • Perceiving what vs. where: vision, somatosensation
  • Functional segregation: examples of
  • Receptive fields: how size varies with perceptual sensitivity

Memory

  • Long-term Potentiation (LTP) involves neuron A’s connection to neuron B ____
  • NMDA receptor opens when sending cell ____ and receiving cell ____.
  • Amnesia
    • ____ is impaired; ____ is spared.
  • NMDA receptors and Hebbian learning
  • Hippocampus size and memory demands

Frontiers in neuroscience

Beyond the connectome

Brain dynamics

Brain/gut connection

Glia

Careers in neuroscience

Job prospects

Employment in healthcare occupations is projected to grow 15 percent from 2019 to 2029, much faster than the average for all occupations, adding about 2.4 million new jobs. Healthcare occupations are projected to add more jobs than any of the other occupational groups. This projected growth is mainly due to an aging population, leading to greater demand for healthcare services.

U.S. Bureau of Labor Statistics

Interviewing

  • Getting an interview
    • Show initiative & impact
  • During interview
    • Come prepared – why this job? why this organization?
    • Dress professionally
    • Be engaged, ask questions

References

Bargmann, C. I. (2012). Beyond the connectome: How neuromodulators shape neural circuits. BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology, 34(6), 458–465. https://doi.org/10.1002/bies.201100185

Breakspear, M. (2017). Dynamic models of large-scale brain activity. Nature Neuroscience, 20(3), 340–352. https://doi.org/10.1038/nn.4497

De Pittà, M., & Berry, H. (2019). A Neuron–Glial perspective for computational neuroscience. In M. De Pittà & H. Berry (Eds.), Computational glioscience (pp. 3–35). Cham: Springer International Publishing. https://doi.org/10.1007/978-3-030-00817-8\_1

Furness, J. B. (2012). The enteric nervous system and neurogastroenterology. Nature Reviews. Gastroenterology & Hepatology, 9(5), 286–294. https://doi.org/10.1038/nrgastro.2012.32