2022-02-17 07:43:40
Monoamines, do-do do do-do Monoamines, do do do-do Monoamines, do do do do-do do do-do do do-do do do do do-do do
Monoamines, do-pa-mine is one Monoamines, norepi, too Monoamines, sero-tonin e-pinephrine, dop-a-mine, nor-epinephrine, melatonin, whoo!
Monoamines, mod-u-late neurons Monoamines, throughout the brain Monoamines, keep people happy, brains snappy, not sleepy, not sappy, do-do do-do do-do do
Type | Receptor | Esp Permeable to |
---|---|---|
Ionotropic | AMPA | Na+, K+ |
Kainate | ||
NMDA | Ca++ | |
Metabotropic | mGlu |
“GABAA-receptor-protein-example” by Chemgirl131 at English Wikipedia - Transferred from
en.wikipedia to Commons by Sreejithk2000 using CommonsHelper.. Licensed under Public Domain via Commons.
Type | Receptor | Esp Permeable to |
---|---|---|
Ionotropic | GABA-A | Cl- |
Metabotropic | GABA-B | K+ |
Type | Receptor | Esp Permeable to | Blocked by |
---|---|---|---|
Ionotropic | Nicotinic (nAChR) | Na+, K+ | e.g., Curare |
Metabotropic | Muscarinic (mAChR) | K+ | e.g., Atropine |
Substance | Effect |
---|---|
Japanese pufferfish toxin | Blocks voltage-gated Na+ channels |
Black widow spider venom | Accelerates presynaptic ACh release |
Botulinum toxin (BoTox) | Prevents ACh vesicles from binding presynaptically |
Sarin nerve gas | Impedes ACh breakdown by AChE |
Pesticides | Impede AChE |
Tetanus toxin | Blocks release of GABA, glycine |
Family | Neurotansmitter |
---|---|
Monoamines | Dopamine (DA) |
Norepinephrine (NE)/Noradrenaline (NAd) | |
Epinephrine (Epi)/Adrenaline (Ad) | |
Serotonin (5-HT) | |
Melatonin | |
Histamine |
Type | Receptor | Comments |
---|---|---|
Metabotropic | D1-like (D1 and D5) | more prevalent |
D2-like (D2, D3, D4) | target of many antipsychotics (drugs that treat schizophrenia symptoms) |
-(-1) = + 1
Type | Receptor | Comments |
---|---|---|
Metabotropic | \(\alpha\) (1,2) | antagonists treat anxiety, panic |
\(\beta\) (1,2,3) | ‘beta blockers’ in cardiac disease |
By Images are generated by Life Science Databases(LSDB). - from Anatomography, website maintained by Life Science Databases(LSDB). You can get this image through URL below. 次のアドレスからこのファイルで使用している画像を取得できます URL., CC BY-SA 2.1 jp, https://commons.wikimedia.org/w/index.php?curid=7855244
Furness, J. B. (2012). The enteric nervous system and neurogastroenterology. Nature Reviews. Gastroenterology & Hepatology, 9(5), 286–294. https://doi.org/10.1038/nrgastro.2012.32
Małgorzata, P., Paweł, K., Iwona, M. L., Brzostek, T., & Andrzej, P. (2020). Glutamatergic dysregulation in mood disorders: Opportunities for the discovery of novel drug targets. Expert Opinion on Therapeutic Targets, 24(12), 1187–1209. https://doi.org/10.1080/14728222.2020.1836160
McCutcheon, R. A., Krystal, J. H., & Howes, O. D. (2020). Dopamine and glutamate in schizophrenia: Biology, symptoms and treatment. World Psychiatry: Official Journal of the World Psychiatric Association, 19(1), 15–33. https://doi.org/10.1002/wps.20693